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Mitoxantrone dihydrochloride (NSC-301739) 是一种拓扑异构酶 II 的抑制剂;也可抑制蛋白激酶C (PKC),IC50值为8.5 μM。
Mitoxantrone dihydrochloride (NSC-301739) 是一种拓扑异构酶 II 的抑制剂;也可抑制蛋白激酶C (PKC),IC50值为8.5 μM。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
25 mg | ¥ 293 | 现货 | |
50 mg | ¥ 429 | 现货 | |
100 mg | ¥ 671 | 现货 | |
500 mg | ¥ 1,675 | 现货 | |
1 mL x 10 mM (in DMSO) | ¥ 474 | 现货 |
产品描述 | Mitoxantrone dihydrochloride (NSC-301739) is the hydrochloride salt of an anthracenedione antibiotic with antineoplastic activity. It is a type II topoisomerase inhibitor. |
靶点活性 | PKC:8.5 μM |
体外活性 | Methotrexate在小鼠气囊炎模型中,Methotrexate的IC50 为每周0.08 mg/kg. |
体内活性 | Methotrexate能够抑制嘌呤和嘧啶的从头合成,多胺的形成以及DNA、RNA、磷脂和蛋白质的转甲基作用。Methotrexate抑制胸苷酸合成酶,使细胞内胸苷酸不足,最终导致抗增殖的细胞毒性作用。Methotrexate通过主动转运或易化扩散进入细胞,在细胞内经过多聚谷氨酸化后,会抑制二氢叶酸还原酶和二氢叶酸转化为四氢叶酸。 |
细胞实验 | The human breast carcinoma cell lines MDA-MB-231 and MCF-7 are seeded in standard 96-well plates. One day after seeding, the culture medium is changed and replaced by medium containing different concentration of Mitoxantrone (10-5 to 5 μM) with or without DHA (30 μM) during 7 days. Viability of cells are measured as a whole by the tetrazolium salt assay[3]. |
别名 | 盐酸米托蒽醌, Mitoxantrone 2HCl, Mitoxantrone hydrochloride, NSC-301739, mitozantrone dihydrochloride, 米托蒽醌二盐酸盐 |
分子量 | 517.4 |
分子式 | C22H30Cl2N4O6 |
CAS No. | 70476-82-3 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 38.8 mg/mL (75 mM) H2O: 2.6 mg/mL (5 mM) | |||||||||||||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||||||||||||
H2O/DMSO
DMSO
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